慢性阻塞性肺疾病急性加重期细菌感染与血气分析的关系
Relationship between pathogenic bacteria and blood gas analysis of chronic obstructive pulmonary disease in acute exacerbation period
目的 调查大连地区慢性阻塞性肺疾病急性加重期(AECOPD)患者病原菌分布特点,探讨其细菌感染与动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)的关系.方法 对2008年12月至2010年3月大连医科大学第一附属医院呼吸科收治的AECOPD患者行痰培养及动脉血气分析,按痰培养结果分为痰培养阳性组和阴性组,比较两组间PaO2与PaCO2的差异.结果 本地区住院AECOPD患者的感染病原菌以革兰阴性杆菌为主.痰培养阳性组的PaO2显著低于痰培养阴性组,PaCO2显著高于痰培养阴性组.结论 检测本地区AECOPD患者细菌谱变化可以为当地的经验性抗生素治疗提供指导.血气分析提示病情危重的患者,常并发细菌感染,应尽早给予合理的抗生素治疗.
更多Objective To survey the distribution feature of pathogenic bacteria in patients with acute exacerbation period of chronic obstructive pulmonary disease (AECOPD) in Dalian and discuss the relationship between bacterial infection and PaO2,PaCO2.Methods Sputum culture and blood gas analysis of patients with AECOPD who were treated in the first affiliated hospital of Dalian medical university between December 2008 and March 2010 were made.The patients were divided into positive group and negative group according to their sputum cultures.The differences of PaO2 and PaCO2 between the two groups were compared.Results The main pathogenic bacteria in patients of this area was gram-negative bacilli.PaO2 of positive group was significantly lower than that of negative group,while the PaCO2 was much higher than that of negative group.Conclusions Detecting the change of bacteria spectrum can provide direction for local empiric antibiotic therapy.The blood gas analysis indicating seriously ill patients often has bacterial infection,and they should receive reasonable antibiotic treatment as soon as possible.
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