换一批Loss of CYP3A7 gene induction by 1,25-dihydroxyvitamin D3 is caused by less binding of VDR to the proximal ER6 in CYP3A7 gene.
第一作者：
Hirokazu,Hara
第一单位：
Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan. harah@gifu-pu.ac.jp
作者：
医学主题词
芳基烃羟化酶类(Aryl Hydrocarbon Hydroxylases);碱基序列(Base Sequence);结合部位(Binding Sites);Caco-2细胞(Caco-2 Cells);骨化三醇(Calcitriol);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);DNA(DNA);基因表达调控(Gene Expression Regulation);基因, 报告(Genes, Reporter);人类(Humans);分子序列数据(Molecular Sequence Data);诱变, 定点(Mutagenesis, Site-Directed);突变(Mutation);启动区, 遗传(Promoter Regions, Genetic);RNA, 信使(RNA, Messenger);受体, 骨化三醇(Receptors, Calcitriol);序列同源性, 核酸(Sequence Homology, Nucleic Acid);转录激活(Transcriptional Activation);转染(Transfection)
DOI
10.1016/j.bbrc.2004.07.043
PMID
15358113
发布时间
2018-12-11
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