换一批Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
第一作者：
Christy J,Fryer
第一单位：
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
作者：
主题词
衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);动物(Animals);碱性螺旋-环-螺旋转录因子类(Basic Helix-Loop-Helix Transcription Factors);印迹法, 蛋白质(Blotting, Western);细胞系, 肿瘤(Cell Line, Tumor);染色质(Chromatin);共同培养技术(Coculture Techniques);细胞周期蛋白依赖激酶8(Cyclin-Dependent Kinase 8);细胞周期蛋白依赖激酶9(Cyclin-Dependent Kinase 9);细胞周期蛋白质依赖激酶类(Cyclin-Dependent Kinases);DNA结合蛋白质类(DNA-Binding Proteins);果蝇蛋白质类(Drosophila Proteins);增强子元件, 遗传学(Enhancer Elements, Genetic);基因, 报告(Genes, Reporter);同源盒结构域蛋白质类(Homeodomain Proteins);人类(Humans);萤光素酶类(Luciferases);膜蛋白质类(Membrane Proteins);小鼠(Mice);核蛋白质类(Nuclear Proteins);骨肉瘤(Osteosarcoma);磷酰化(Phosphorylation);点突变(Point Mutation);沉淀素试验(Precipitin Tests);启动区, 遗传(Promoter Regions, Genetic);蛋白质结构, 三级(Protein Structure, Tertiary);受体, Notch(Receptors, Notch);信号传导(Signal Transduction);反式激活因子类(Trans-Activators);转录因子(Transcription Factors);转录激活(Transcriptional Activation);转化生长因子β(Transforming Growth Factor beta);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)
DOI
10.1016/j.molcel.2004.10.014
PMID
15546612
发布时间
2022-12-27
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Molecular cell
509-20页
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