换一批Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis.
第一作者：
A C,Riggs
第一单位：
Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, MO 63110-1010, USA.
作者：
医学主题词
动物(Animals);细胞凋亡(Apoptosis);血糖(Blood Glucose);细胞增殖(Cell Proliferation);内质网(Endoplasmic Reticulum);基因表达调控(Gene Expression Regulation);葡糖耐量试验(Glucose Tolerance Test);胰岛素(Insulin);胰岛素分泌细胞(Insulin-Secreting Cells);胰岛素瘤(Insulinoma);男(雄)性(Male);膜蛋白质类(Membrane Proteins);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);器官特异性(Organ Specificity);胰腺肿瘤(Pancreatic Neoplasms);表型(Phenotype)
DOI
10.1007/s00125-005-1947-4
PMID
16215705
发布时间
2022-03-17
- 浏览15
Diabetologia
2313-21页
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