Large-scale allosteric conformational transitions of adenylate kinase appear to involve a population-shift mechanism.
第一作者:
Karunesh,Arora
第一单位:
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
作者:
医学主题词
腺苷酸激酶(Adenylate Kinase);别构调节(Allosteric Regulation);计算机模拟(Computer Simulation);结晶学, X线(Crystallography, X-Ray);酶激活(Enzyme Activation);配体(Ligands);模型, 分子(Models, Molecular);蛋白质结合(Protein Binding);蛋白激酶抑制剂(Protein Kinase Inhibitors);蛋白质结构, 三级(Protein Structure, Tertiary)
DOI
10.1073/pnas.0706443104
PMID
18000050
发布时间
2021-10-20
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