换一批Design, synthesis, and biological evaluation of (2R,alphaS)-3,4-dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-alpha-(trifluoromethyl)-1(2H)-quinolineethanol as potent and orally active cholesteryl ester transfer protein inhibitor.
第一作者：
Gee-Hong,Kuo
第一单位：
Drug Discovery Division, Johnson and Johnson Pharmaceutical Research and Development, LLC 8 Clarke Drive, Cranbury, New Jersey 08512, USA. gkuo@its.jnj.com
作者：
医学主题词
投药, 口服(Administration, Oral);动物(Animals);胆固醇酯转运蛋白质类(Cholesterol Ester Transfer Proteins);仓鼠亚科(Cricetinae);膳食脂肪类(Dietary Fats);药物设计(Drug Design);人类(Humans);成束猴(Macaca fascicularis);磁共振波谱学(Magnetic Resonance Spectroscopy);小鼠(Mice);喹啉类(Quinolines);光谱法, 质量, 电喷雾电离(Spectrometry, Mass, Electrospray Ionization)
DOI
10.1021/jm801319d
PMID
19236017
发布时间
2009-03-19
- 浏览23
Journal of medicinal chemistry
1768-72页
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