换一批Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.
第一作者：
Marvin J,Meyers
第一单位：
St. Louis Laboratories, Pfizer Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, Missouri 63017, USA. mmeyers8@slu.edu
作者：
医学主题词
动物(Animals);抗高血压药(Antihypertensive Agents);血压(Blood Pressure);细胞系, 肿瘤(Cell Line, Tumor);氯苯类(Chlorobenzenes);结晶学, X线(Crystallography, X-Ray);人类(Humans);高血压(Hypertension);吲唑类(Indazoles);茚类(Indenes);肾疾病(Kidney Diseases);男(雄)性(Male);模型, 分子(Models, Molecular);分子构象(Molecular Conformation);腈类(Nitriles);放射配体测定(Radioligand Assay);大鼠(Rats);大鼠, 近交Dahl(Rats, Inbred Dahl);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);立体异构现象(Stereoisomerism);构效关系(Structure-Activity Relationship)
DOI
10.1021/jm100505n
PMID
20672822
发布时间
2021-12-03
- 浏览88
Journal of medicinal chemistry
5979-6002页
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