换一批Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.
第一作者：
Adrian,Huang
第一单位：
Pfizer Global Research and Development, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA.
作者：
医学主题词
投药, 口服(Administration, Oral);动物(Animals);Caco-2细胞(Caco-2 Cells);颈动脉损伤(Carotid Artery Injuries);细胞膜通透性(Cell Membrane Permeability);狗(Dogs);药物稳定性(Drug Stability);人类(Humans);羟喹啉类(Hydroxyquinolines);白细胞滚动(Leukocyte Rolling);成束猴(Macaca fascicularis);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);微粒体, 肝(Microsomes, Liver);模型, 分子(Models, Molecular);P选择素(P-Selectin);狒狒属(Papio);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);水杨酸盐类(Salicylates);溶解度(Solubility);构效关系(Structure-Activity Relationship);静脉血栓形成(Venous Thrombosis)
DOI
10.1021/jm9013696
PMID
20718494
发布时间
2012-11-15
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