换一批A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
第一作者：
Kanokkarn,Phromnoi
第一单位：
Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 143, Houston, TX 77030, USA.
作者：
医学主题词
血管生成诱导剂(Angiogenesis Inducing Agents);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);碱基序列(Base Sequence);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);减量调节(Down-Regulation);酶激活(Enzyme Activation);类黄酮物质(Flavonoids);基因, 报告(Genes, Reporter);人类(Humans);I-κB激酶(I-kappa B Kinase);免疫组织化学(Immunohistochemistry);寡脱氧核糖核苷酸类(Oligodeoxyribonucleotides);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)
DOI
10.1124/mol.110.067512
PMID
20930110
发布时间
2025-02-13
- 浏览17
Molecular pharmacology
279-89页
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