换一批Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells.
第一作者：
Michelle,Kiebala
第一单位：
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America.
作者：
主题词
动物(Animals);酶激活(Enzyme Activation);HIV-1(HIV-1);人类(Humans);炎症介导素类(Inflammation Mediators);小鼠(Mice);小神经胶质细胞(Microglia);NF-κB(NF-kappa B);磷酸二酯酶抑制剂(Phosphodiesterase Inhibitors);磷蛋白磷酸酶类(Phosphoprotein Phosphatases);吡啶类(Pyridines);受体, 腺苷A2A(Receptor, Adenosine A2A);信号传导(Signal Transduction);转录, 遗传(Transcription, Genetic);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases);tat基因产物, 人免疫缺陷病毒(tat Gene Products, Human Immunodeficiency Virus)
DOI
10.1371/journal.pone.0018633
PMID
21494611
发布时间
2022-03-18
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