Structural basis for dual-inhibition mechanism of a non-classical Kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin.
第一作者:
Rajesh T,Shenoy
第一单位:
Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
作者:
主题词
氨基酸序列(Amino Acid Sequence);动物(Animals);芽孢杆菌属(Bacillus);量热法(Calorimetry);催化域(Catalytic Domain);结晶学, X线(Crystallography, X-Ray);鲎(Horseshoe Crabs);模型, 分子(Models, Molecular);分子序列数据(Molecular Sequence Data);肽类(Peptides);蛋白质结构, 二级(Protein Structure, Secondary);蛋白质结构, 三级(Protein Structure, Tertiary);序列比对(Sequence Alignment);构效关系(Structure-Activity Relationship);枯草杆菌蛋白酶(Subtilisin);胰蛋白酶抑制剂, Kazal胰腺(Trypsin Inhibitor, Kazal Pancreatic)
DOI
10.1371/journal.pone.0018838
PMID
21541315
发布时间
2021-10-20
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