Hwanggeumchal sorghum induces cell cycle arrest, and suppresses tumor growth and metastasis through Jak2/STAT pathways in breast cancer xenografts.
作者:
主题词
动物(Animals);抗肿瘤药, 植物(Antineoplastic Agents, Phytogenic);乳腺肿瘤(Breast Neoplasms);细胞增殖(Cell Proliferation);剂量效应关系, 药物(Dose-Response Relationship, Drug);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);Janus激酶2(Janus Kinase 2);肺肿瘤(Lung Neoplasms);小鼠(Mice);小鼠, 裸(Mice, Nude);肿瘤转移(Neoplasm Metastasis);癌基因蛋白质类(Oncogene Proteins);植物提取物(Plant Extracts);启动区, 遗传(Promoter Regions, Genetic);蛋白质结合(Protein Binding);受体, IGF1型(Receptor, IGF Type 1);STAT转录因子类(STAT Transcription Factors);STAT3转录因子(STAT3 Transcription Factor);STAT5转录因子(STAT5 Transcription Factor);信号传导(Signal Transduction);高梁属(Sorghum);肿瘤抑制蛋白质类(Tumor Suppressor Proteins);血管内皮生长因子A(Vascular Endothelial Growth Factor A);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1371/journal.pone.0040531
PMID
22792362
发布时间
2024-11-03
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