The effects of simvastatin or interferon-α on infectivity of human norovirus using a gnotobiotic pig model for the study of antivirals.
作者:
主题词
动物(Animals);抗病毒药(Antiviral Agents);血型抗原(Blood Group Antigens);嵌杯病毒科感染(Caliciviridae Infections);胆固醇(Cholesterol);树突细胞(Dendritic Cells);疾病模型, 动物(Disease Models, Animal);疾病易感性(Disease Susceptibility);肠细胞(Enterocytes);粪便(Feces);基因表达调控(Gene Expression Regulation);无菌生物(Germ-Free Life);人类(Humans);干扰素调节因子3(Interferon Regulatory Factor-3);干扰素α(Interferon-alpha);肠(Intestines);巨噬细胞(Macrophages);NF-κB(NF-kappa B);诺罗病毒(Norovirus);表型(Phenotype);受体, LDL(Receptors, LDL);斯伐他汀(Simvastatin);野猪(Sus scrofa);Toll样受体3(Toll-Like Receptor 3);病毒载量(Viral Load);病毒复制(Virus Replication);病毒脱落(Virus Shedding)
DOI
10.1371/journal.pone.0041619
PMID
22911825
发布时间
2021-10-21
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