首页> Journal of medicinal chemistry> Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.

Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.

导出 LinkOut

翻译打印收藏纠错

第一作者： Alan B,Northrup

第一单位： Department of Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, BMB-3, Boston, Massachusetts 02115, USA. alan_northrup@merck.com

作者： Alan B,Northrup ^[1] ; Matthew H,Katcher ; Michael D,Altman ; Melissa,Chenard ; Matthew H,Daniels ; Sujal V,Deshmukh ; Danielle,Falcone ; David J,Guerin ; Harold,Hatch ; Chaomin,Li ; Wei,Lu ; Bart,Lutterbach ; Timothy J,Allison ; Sangita B,Patel ; John F,Reilly ; Michael,Reutershan ; Keith W,Rickert ; Craig,Rosenstein ; Stephen M,Soisson ; Alexander A,Szewczak ; Deborah,Walker ; Kevin,Wilson ; Jonathan R,Young ; Bo-Sheng,Pan ; Christopher J,Dinsmore

作者单位： Department of Chemistry, Merck & Co., Inc. , 33 Avenue Louis Pasteur, BMB-3, Boston, Massachusetts 02115, USA. alan_northrup@merck.com ^[1]