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Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells.

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第一作者： Janna,Schneppenheim

第一单位： Biochemical Institute, Christian Albrechts University of Kiel, Kiel, Germany.

作者： Janna,Schneppenheim ^[1] ; Susann,Hüttl ^[1] ; Anne,Kruchen ^[2] ; Regina,Fluhrer ^[3] ; Ingo,Müller ^[4] ; Paul,Saftig ^[1] ; Reinhard,Schneppenheim ^[4] ; Christa L,Martin ^[5] ; Bernd,Schröder ^[6]

作者单位： Biochemical Institute, Christian Albrechts University of Kiel, Kiel, Germany. ^[1] Research Institute Children's Cancer Center, Hamburg, Germany. ^[2] Adolf-Butenandt-Institute for Biochemistry, Ludwig Maximilians University of Munich, Munich, Germany; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany. ^[3] Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[4] Autism and Developmental Medicine Institute, Geisinger Health System, Danville, PA, USA. ^[5] Biochemical Institute, Christian Albrechts University of Kiel, Kiel, Germany. Electronic address: baschroeder@biochem.uni-kiel.de. ^[6]

关键词 B cell maturation CD74 Common variable immune deficiency Intramembrane proteolysis Invariant chain Signal-peptide-peptidase-like protease