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Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors.

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第一作者： Ramakrishna,Edupuganti

第一单位： Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, TX 78712, USA; Department of Chemistry, The University of Texas at Austin, TX 78712, USA.

作者： Ramakrishna,Edupuganti ^[1] ; Qiantao,Wang ^[2] ; Clint D J,Tavares ^[3] ; Catrina A,Chitjian ^[3] ; James L,Bachman ^[4] ; Pengyu,Ren ^[5] ; Eric V,Anslyn ^[6] ; Kevin N,Dalby ^[7]

作者单位： Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, TX 78712, USA; Department of Chemistry, The University of Texas at Austin, TX 78712, USA. ^[1] Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, TX 78712, USA; Department of Biomedical Engineering, Cockrell School of Engineering, College of Engineering, The University of Texas at Austin, TX 78712, USA. ^[2] Graduate Program in Cell and Molecular Biology, The University of Texas at Austin, TX 78712, USA. ^[3] Department of Chemistry, The University of Texas at Austin, TX 78712, USA. ^[4] Department of Biomedical Engineering, Cockrell School of Engineering, College of Engineering, The University of Texas at Austin, TX 78712, USA. ^[5] Department of Chemistry, The University of Texas at Austin, TX 78712, USA. Electronic address: anslyn@austin.utexas.edu. ^[6] Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, TX 78712, USA; Graduate Program in Cell and Molecular Biology, The University of Texas at Austin, TX 78712, USA. Electronic address: dalby@austin.utexas.edu. ^[7]

关键词 Homology modeling Kinase inhibitor Pyrido[2,3-d]pyrimidine-2,4-dione Uracil eEF-2K inhibitor