Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteome.

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第一作者： Bin,Tang

第一单位： Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, China 200241; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China 200241;

作者： Bin,Tang ^[1] ; Tingting,Wang ^[1] ; Huida,Wan ^[1] ; Li,Han ^[2] ; Xiaoyan,Qin ^[1] ; Yaoyang,Zhang ^[3] ; Jian,Wang ^[4] ; Chunlei,Yu ^[1] ; Fulvia,Berton ^[5] ; Walter,Francesconi ^[6] ; John R,Yates ^[5] ; Peter W,Vanderklish ^[7] ; Lujian,Liao ^[8]

作者单位： Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, China 200241; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China 200241; ^[1] Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China 200031; ^[2] Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China 200032; ^[3] School of Life Sciences, Shanghai University, Shanghai, China 200444; ^[4] Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037; ^[5] Department of Molecular and Cellular Neuronscience, The Scripps Research Institute, La Jolla, CA 92037; ^[6] Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037. ^[7] Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, China 200241; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China 200241; ljliao@bio.ecnu.edu.cn. ^[8]

关键词 autism fragile X quantitative mass spectrometry stable isotope labeling synaptic protein synthesis