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The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis.

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第一作者： Jordi,Heijman

第一单位： Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands.

作者： Jordi,Heijman ^[1] ; Vincent,Algalarrondo ^[2] ; Niels,Voigt ^[3] ; Jonathan,Melka ^[2] ; Xander H T,Wehrens ^[4] ; Dobromir,Dobrev ^[5] ; Stanley,Nattel ^[6]

作者单位： Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands. ^[1] Department of Medicine, Montreal Heart Institute and Université de Montréal, 5000 Belanger St. E., Montreal, Canada H1T 1C8 Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada. ^[2] Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Hufelandstr. 55, D-45122 Essen, Germany. ^[3] Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA Department of Medicine (Cardiology), Baylor College of Medicine, Houston, TX, USA Pediatrics, Baylor College of Medicine, Houston, TX, USA. ^[4] Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Hufelandstr. 55, D-45122 Essen, Germany dobromir.dobrev@uk-essen.de stanley.nattel@icm-mhi.org. ^[5] Department of Medicine, Montreal Heart Institute and Université de Montréal, 5000 Belanger St. E., Montreal, Canada H1T 1C8 Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Hufelandstr. 55, D-45122 Essen, Germany dobromir.dobrev@uk-essen.de stanley.nattel@icm-mhi.org. ^[6]

关键词 Ablation Antiarrhythmic drugs Atrial fibrillation Cellular electrophysiology Ectopic activity Imaging Re-entry