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Structure-activity relationships of benzothiazole GPR35 antagonists.

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第一作者： Manahil M,Abdalhameed

第一单位： Department of Chemistry and Biochemistry, Natural Products and Drug Discovery Center, University of North Carolina at Greensboro, Greensboro, NC 27402, United States.

作者： Manahil M,Abdalhameed ^[1] ; Pingwei,Zhao ^[2] ; Dow P,Hurst ^[1] ; Patricia H,Reggio ^[3] ; Mary E,Abood ^[4] ; Mitchell P,Croatt ^[5]

作者单位： Department of Chemistry and Biochemistry, Natural Products and Drug Discovery Center, University of North Carolina at Greensboro, Greensboro, NC 27402, United States. ^[1] Department of Anatomy and Cell Biology and Center for Substance Abuse Research, Temple University, Philadelphia, PA 19140, United States. ^[2] Department of Chemistry and Biochemistry, Natural Products and Drug Discovery Center, University of North Carolina at Greensboro, Greensboro, NC 27402, United States. Electronic address: phreggio@uncg.edu. ^[3] Department of Anatomy and Cell Biology and Center for Substance Abuse Research, Temple University, Philadelphia, PA 19140, United States. Electronic address: mabood@temple.edu. ^[4] Department of Chemistry and Biochemistry, Natural Products and Drug Discovery Center, University of North Carolina at Greensboro, Greensboro, NC 27402, United States. Electronic address: mpcroatt@uncg.edu. ^[5]

关键词 Antagonist Benzothiazole G protein-coupled receptor GPR35 SAR

医学主题词苯并噻唑类(Benzothiazoles);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);蛋白质结合(Protein Binding);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmcl.2016.12.012

PMID 27989666

发布时间 2018-11-13

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