Oral delivery of exenatide-loaded hybrid zein nanoparticles for stable blood glucose control and β-cell repair of type 2 diabetes mice.
作者:
Xiaoyan,Bao [1]
;
Kang,Qian [2]
;
Ping,Yao [3]
作者单位:
State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Polymers and Polymer Composite Materials, Department of Macromolecular Science, Fudan University, Shanghai, 200438, China.
[1]
Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, 201203, China.
[2]
State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Polymers and Polymer Composite Materials, Department of Macromolecular Science, Fudan University, Shanghai, 200438, China. yaoping@fudan.edu.cn.
[3]
主题词:
投药, 口服(Administration, Oral);动物(Animals);血糖(Blood Glucose);胆酸(Cholic Acid);糖尿病, 2型(Diabetes Mellitus, Type 2);药物载体(Drug Carriers);胃肠道(Gastrointestinal Tract);半衰期(Half-Life);降血糖药(Hypoglycemic Agents);胰岛素分泌细胞(Insulin-Secreting Cells);肠黏膜(Intestinal Mucosa);男(雄)性(Male);小鼠(Mice);小鼠, 近交ICR(Mice, Inbred ICR);纳米粒子(Nanoparticles);通透性(Permeability);磷脂酰胆碱类(Phosphatidylcholines);玉米醇溶蛋白(Zein)
DOI:
10.1186/s12951-020-00619-0
PMID:
32345323
发布时间:
2022-12-07
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