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Trans-generational epigenetic regulation associated with the amelioration of Duchenne Muscular Dystrophy.

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第一作者： Julie,Martone

第一单位： Department of Biology and Biotechnology, 'Charles Darwin', Sapienza University of Rome, Rome, Italy.;CNR Institute of Molecular Biology and Pathology (IBPM), Rome, Italy.

作者： Julie,Martone ^[1] ; Michela,Lisi ^[2] ; Francesco,Castagnetti ^[3] ; Alessandro,Rosa ^[4] ; Valerio,Di Carlo ^[5] ; Enrique,Blanco ^[5] ; Adriano,Setti ^[2] ; Davide,Mariani ^[6] ; Alessio,Colantoni ^[2] ; Tiziana,Santini ^[7] ; Lucia,Perone ^[8] ; Luciano,Di Croce ^[9] ; Irene,Bozzoni ^[10]

作者单位： Department of Biology and Biotechnology, 'Charles Darwin', Sapienza University of Rome, Rome, Italy.;CNR Institute of Molecular Biology and Pathology (IBPM), Rome, Italy. ^[1] Department of Biology and Biotechnology, 'Charles Darwin', Sapienza University of Rome, Rome, Italy. ^[2] Department of Biology and Biotechnology, 'Charles Darwin', Sapienza University of Rome, Rome, Italy.;Center for Human Technologies, Istituto Italiano di Tecnologia, Genova, Italy. ^[3] Department of Biology and Biotechnology, 'Charles Darwin', Sapienza University of Rome, Rome, Italy.;Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy. ^[4] Center for Genomic Regulation, Barcelona, Spain. ^[5] Center for Human Technologies, Istituto Italiano di Tecnologia, Genova, Italy. ^[6] Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy. ^[7] Cell Culture and Cytogenetics Core, Telethon Institute of Genetics and Medicine, Pozzuoli, Italy. ^[8] Center for Genomic Regulation, Barcelona, Spain.;Universitat Pompeu Fabra (UPF), Barcelona, Spain.;Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. ^[9] Department of Biology and Biotechnology, 'Charles Darwin', Sapienza University of Rome, Rome, Italy.;CNR Institute of Molecular Biology and Pathology (IBPM), Rome, Italy.;Center for Human Technologies, Istituto Italiano di Tecnologia, Genova, Italy.;Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy. ^[10]

关键词 ATAC sequencing DMD Exon skipping iPSC Reprogramming lncRNAs trans-generational epigenetic inheritance

医学主题词肌营养不良蛋白(Dystrophin);后成说, 遗传(Epigenesis, Genetic);外显子(Exons);人类(Humans);肌营养不良, 杜氏(Muscular Dystrophy, Duchenne);寡核苷酸类, 反义(Oligonucleotides, Antisense)

DOI 10.15252/emmm.202012063

PMID 32596946

发布时间 2021-08-18

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