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Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells.

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第一作者： Rebecca,San Gil

第一单位： Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.;Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia.;Neurodegeneration Pathobiology Laboratory, Queensland Brain Institute, University of Queensland, St Lucia, QLD 4072, Australia.

作者： Rebecca,San Gil ^[1] ; Dezerae,Cox ^[2] ; Luke,McAlary ^[3] ; Tracey,Berg ^[3] ; Adam K,Walker ^[4] ; Justin J,Yerbury ^[3] ; Lezanne,Ooi ^[3] ; Heath,Ecroyd ^[5]

作者单位： Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.;Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia.;Neurodegeneration Pathobiology Laboratory, Queensland Brain Institute, University of Queensland, St Lucia, QLD 4072, Australia. ^[1] Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3052, Australia. ^[2] Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.;Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia. ^[3] Neurodegeneration Pathobiology Laboratory, Queensland Brain Institute, University of Queensland, St Lucia, QLD 4072, Australia. ^[4] Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia heathe@uow.edu.au.;Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia. ^[5]

关键词 HSF1 Heat shock response Inclusions Neurodegenerative disorders Protein aggregation

医学主题词热休克反应(Heat-Shock Response);人类(Humans);神经变性疾病(Neurodegenerative Diseases)

DOI 10.1242/jcs.243709

PMID 32661089

发布时间 2021-06-18

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