Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity.

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第一作者： Dong,Huang

第一单位： Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.

作者： Dong,Huang ^[1] ; Ying-Yuan,Zhao ^[1] ; Rui-Min,Wang ^[1] ; Wei,Li ^[1] ; Fang-Yu,Yuan ^[1] ; Xue-Long,Yan ^[1] ; Xiao,Yang ^[1] ; Gui-Hua,Tang ^[1] ; Sheng,Yin ^[2] ; Hui-Chang,Bi ^[3]

作者单位： Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. ^[1] Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. yinsh2@mail.sysu.edu.cn. ^[2] Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. bihchang@mail.sysu.edu.cn.;NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China. bihchang@mail.sysu.edu.cn. ^[3]

关键词 Euphorbiaceae PXR agonist anti-cholestasis drugs cholestasis lathyrane diterpenoid pregnane X receptor

主题词动物(Animals);生物制品(Biological Products);胆汁淤积(Cholestasis);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);人类(Humans);肝疾病(Liver Diseases);小鼠(Mice)

DOI 10.1038/s41401-021-00793-3

PMID 34931017

发布时间 2023-08-02

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