Condensates induced by transcription inhibition localize active chromatin to nucleoli.

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第一作者： Takaaki,Yasuhara

第一单位： Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, the University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.

作者： Takaaki,Yasuhara ^[1] ; Yu-Hang,Xing ^[2] ; Nicholas C,Bauer ^[3] ; Lukuo,Lee ^[2] ; Rui,Dong ^[2] ; Tribhuwan,Yadav ^[4] ; Roy J,Soberman ^[3] ; Miguel N,Rivera ^[5] ; Lee,Zou ^[6]

作者单位： Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, the University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan. ^[1] Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. ^[2] Nephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. ^[3] Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA. ^[4] Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. ^[5] Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: zou.lee@mgh.harvard.edu. ^[6]

关键词 chromatin compartment gene fusion nucleolus phase separation rRNA transcription

主题词细胞核仁(Cell Nucleolus);染色质(Chromatin);DNA断裂, 双链(DNA Breaks, Double-Stranded);RNA聚合酶Ⅱ(RNA Polymerase II);RNA, 核糖体(RNA, Ribosomal);转录, 遗传(Transcription, Genetic)

DOI 10.1016/j.molcel.2022.05.010

PMID 35662392

发布时间 2023-08-05

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