Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools.

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第一作者： Chunyi,Hu

第一单位： Department of Molecular Biology and Genetics, Cornell University, 253 Biotechnology Building, Ithaca, NY 14853, USA.

作者： Chunyi,Hu ^[1] ; Dongchun,Ni ^[2] ; Ki Hyun,Nam ^[3] ; Sonali,Majumdar ^[4] ; Justin,McLean ^[4] ; Henning,Stahlberg ^[2] ; Michael P,Terns ^[4] ; Ailong,Ke ^[5]

作者单位： Department of Molecular Biology and Genetics, Cornell University, 253 Biotechnology Building, Ithaca, NY 14853, USA. ^[1] Laboratory of Biological Electron Microscopy, Institute of Physics, Faculty of Basic Sciences, Swiss Federal Institute of Technology (EPFL), Cubotron, Route de la Sorge, 1015 Lausanne, Switzerland; Department of Fundamental Biology, Faculty of Biology and Medicine, University of Lausanne (UNIL), 1011 Lausanne, Switzerland. ^[2] Department of Life Science, Pohang University of Science and Technology, Pohang, Gyeongbuk, Republic of Korea. ^[3] Department of Biochemistry and Molecular Biology, Department of Genetics, and Department of Microbiology, University of Georgia, Athens, GA 30602, USA. ^[4] Department of Molecular Biology and Genetics, Cornell University, 253 Biotechnology Building, Ithaca, NY 14853, USA. Electronic address: ailong.ke@cornell.edu. ^[5]

关键词 CRISPR Cas3 deletion genome editing nucleic acid detection type I CRISPR-Cas

主题词冷冻电子显微镜检查(Cryoelectron Microscopy);DNA(DNA);内切核酸酶类(Endonucleases);人类(Humans);RNA(RNA)

DOI 10.1016/j.molcel.2022.06.007

PMID 35835111

发布时间 2024-09-02

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