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The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages.

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第一作者： Phoenix,Toboz

第一单位： Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, 60612.

作者： Phoenix,Toboz ^[1] ; Mehdi,Amiri ^[2] ; Negar,Tabatabaei ^[1] ; Catherine R,Dufour ^[3] ; Seung Hyeon,Kim ^[1] ; Carine,Fillebeen ^[4] ; Charles E,Ayemoba ^[1] ; Arkady,Khoutorsky ^[5] ; Manfred,Nairz ^[6] ; Lijian,Shao ^[1] ; Kostandin V,Pajcini ^[1] ; Ki-Wook,Kim ^[1] ; Vincent,Giguère ^[2] ; Regiana L,Oliveira ^[7] ; Marco,Constante ^[8] ; Manuela M,Santos ^[8] ; Carlos R,Morales ^[7] ; Kostas,Pantopoulos ^[4] ; Nahum,Sonenberg ^[2] ; Sandra,Pinho ^[1] ; Soroush,Tahmasebi ^[1]

作者单位： Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, 60612. ^[1] Department of Biochemistry, McGill University, Montreal, QC, H3A 1A3, Canada.;Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada. ^[2] Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada. ^[3] Lady Davis Institute for Medical Research, Jewish General Hospital and Department of Medicine, McGill University, Montreal, QC, H3T 1E2, Canada. ^[4] Department of Anesthesia and Faculty of Dentistry, McGill University, Montreal, QC, H3A 0G1, Canada. ^[5] Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, 6020, Austria. ^[6] Department of Anatomy and Cell Biology, McGill University, Montreal, QC, H3G 1Y6, Canada. ^[7] Nutrition and Microbiome Laboratory, Centre de recherche du CHUM and Department of Medicine, Université de Montréal, Montréal, QC, H3X 0A9, Canada. ^[8]

关键词 GCN2 RBC hemolytic stress mRNA translation macrophages