首页> Journal of Alzheimer's disease : JAD> Deletion of the Homocysteine Thiolactone Detoxifying Enzyme Bleomycin Hydrolase, in Mice, Causes Memory and Neurological Deficits and Worsens Alzheimer's Disease-Related Behavioral and Biochemical Traits in the 5xFAD Model of Alzheimer's Disease.

Deletion of the Homocysteine Thiolactone Detoxifying Enzyme Bleomycin Hydrolase, in Mice, Causes Memory and Neurological Deficits and Worsens Alzheimer's Disease-Related Behavioral and Biochemical Traits in the 5xFAD Model of Alzheimer's Disease.

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第一作者： Łukasz,Witucki

第一单位： Department of Biochemistry and Biotechnology, Poznań University of Life Sciences, Poznań, Poland.;Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University, New Jersey Medical School, International Center for Public Health, Newark, NJ, USA.

作者： Łukasz,Witucki ^[1] ; Kamila,Borowczyk ^[2] ; Joanna,Suszyńska-Zajczyk ^[3] ; Ewelina,Warzych ^[4] ; Piotr,Pawlak ^[4] ; Hieronim,Jakubowski ^[1]

作者单位： Department of Biochemistry and Biotechnology, Poznań University of Life Sciences, Poznań, Poland.;Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University, New Jersey Medical School, International Center for Public Health, Newark, NJ, USA. ^[1] Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University, New Jersey Medical School, International Center for Public Health, Newark, NJ, USA. ^[2] Department of Biochemistry and Biotechnology, Poznań University of Life Sciences, Poznań, Poland. ^[3] Department of Genetics and Animal Breeding, Poznań University of Life Sciences, Poznań, Poland. ^[4]

关键词 Alzheimer’s disease Blmh-/-5xFAD mouse H4K20me1 N2a-APPswe mouse neuroblastoma cells Phf8 amyloid-β protein precursor autophagy bleomycin hydrolase homocysteine thiolactone mTOR