Nucleic acid degradation as barrier to gene delivery: a guide to understand and overcome nuclease activity.

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作者： Heyang,Zhang ^[1] ; Jo,Vandesompele ^[2] ; Kevin,Braeckmans ^[3] ; Stefaan C,De Smedt ^[4] ; Katrien,Remaut ^[1]

作者单位： Laboratory for General Biochemistry and Physical Pharmacy, Department of Pharmaceutical Sciences, Ghent University, 9000 Ghent, Belgium. Katrien.remaut@ugent.be. ^[1] Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden, The Netherlands. ^[2] Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium. ^[3] Cancer Research Institute Ghent (CRIG), Ghent, Belgium. ^[4] Centre for Nano- and Biophotonics, Ghent University, 9000 Ghent, Belgium. ^[5]

主题词人类(Humans);基因转移技术(Gene Transfer Techniques);核酸类(Nucleic Acids);疾病大流行(Pandemics);动物(Animals);哺乳动物(Mammals)

DOI 10.1039/d3cs00194f

PMID 38073448

发布时间 2024-01-16

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准确一般字义偏差语意偏离译文作用小提交