ADORA2B, transcriptionally suppressing by MYC, promotes ferroptosis of chondrocytes via inhibition of the PI3K/Akt pathway in mice with osteoarthritis.

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第一作者： Shen,Li

第一单位： Department of Orthopedics, The First Affiliated Hospital of Xi'an JiaoTong University, Xi'an, China.;Department of Orthopedics, Xi'an Chang'an District Hospital, Xi'an, China.

作者： Shen,Li ^[1] ; Jiangbo,Han ^[2] ; Jiongzhe,Cao ^[2] ; Hong,Han ^[2] ; Bin,Lu ^[3] ; Tao,Wen ^[2] ; Weiguo,Bian ^[4]

作者单位： Department of Orthopedics, The First Affiliated Hospital of Xi'an JiaoTong University, Xi'an, China.;Department of Orthopedics, Xi'an Chang'an District Hospital, Xi'an, China. ^[1] Department of Orthopedics, Xi'an Chang'an District Hospital, Xi'an, China. ^[2] Department of Anesthesiology, Xi'an Chang'an District Hospital, Xi'an, China. ^[3] Department of Orthopedics, The First Affiliated Hospital of Xi'an JiaoTong University, Xi'an, China. ^[4]

关键词 ADORA2B MYC PI3K/Akt pathway ferroptosis osteoarthritis

主题词动物(Animals);小鼠(Mice);软骨细胞(Chondrocytes);骨关节炎(Osteoarthritis);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt)

DOI 10.1002/tox.24131

PMID 38174997

发布时间 2024-05-06

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准确一般字义偏差语意偏离译文作用小提交