The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms.
第一作者:
Mohammad Nafees,Ansari
第一单位:
Amity Institute of Integrative Sciences and Health, Amity University Haryana, Gurgaon, Haryana, India.;National Institute of Immunology, New Delhi, India.
作者:
医学主题词
人类(Humans);乳腺肿瘤(Breast Neoplasms);女(雌)性(Female);后成说, 遗传(Epigenesis, Genetic);动物(Animals);神经节苷脂类(Gangliosides);小鼠(Mice);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);疾病恶化(Disease Progression);细胞系, 肿瘤(Cell Line, Tumor);信号传导(Signal Transduction);细胞增殖(Cell Proliferation);转录, 遗传(Transcription, Genetic)
DOI
10.1371/journal.pbio.3003362
PMID
40934285
发布时间
2025-09-15
- 浏览0
PLoS biology
e3003362页
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