换一批Identification of the tissue inhibitor of metalloproteinases-2 (TIMP-2) binding site on the hemopexin carboxyl domain of human gelatinase A by site-directed mutagenesis. The hierarchical role in binding TIMP-2 of the unique cationic clusters of hemopexin modules III and IV.
第一作者：
C M,Overall
第一单位：
Faculty of Dentistry and the Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. overall@interchange.ubc.ca
作者：
医学主题词
氨基酸序列(Amino Acid Sequence);动物(Animals);结合部位(Binding Sites);CHO细胞(CHO Cells);仓鼠亚科(Cricetinae);明胶酶类(Gelatinases);血液结合素(Hemopexin);人类(Humans);基质金属蛋白酶2(Matrix Metalloproteinase 2);金属内肽酶类(Metalloendopeptidases);模型, 分子(Models, Molecular);分子序列数据(Molecular Sequence Data);分子量(Molecular Weight);诱变, 定点(Mutagenesis, Site-Directed);蛋白质构象(Protein Conformation);序列比对(Sequence Alignment);金属蛋白酶2组织抑制剂(Tissue Inhibitor of Metalloproteinase-2)
DOI
10.1074/jbc.274.7.4421
PMID
9933646
发布时间
2021-02-09
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