摘要目的 探讨国产注射用比伐卢定(domestic bivalirudin)对大鼠颈总动脉血栓模型血小板活化功能的影响.方法 建立大鼠左颈总动脉血栓模型,分为对照组(n=6)、模型组(n=10)、国产注射用比伐卢定联合尿激酶(urokinase,UK)组(B&UK组,n=10)、肝素(heparin)联合尿激酶组(H&UK组,n=10),检测各组治疗前后GMP-140含量及血栓重量.结果 与模型组比较,B&UK组及H&UK组血栓重量均明显减轻,而B&UK组与H&UK组之间血栓重量比较差异无统计学意义.模型组、B&UK组及H&UK组GMP-140含量均显著高于对照组；而治疗后GMP-140含量在B&UK组显著低于模型组,相反治疗后GMP-140含量在H&UK组则显著高于模型组.结论 国产注射用比伐卢定能在模型中有效抑制血栓形成,但相比肝素,国产注射用比伐卢定能显著抑制血小板活化功能,抑制血小板聚集.在抑制血栓形成过程中国产注射用比伐卢定对血小板活化的影响具有更多优势.

abstractsObjectives To explore the effect of domestic bivalirudin on platelet activation function in rat model of carotid artery thrombosis.Methods A rat model of common carotid artery thrombosis was established.The rats were then randomized to control group (n =6),model group (n =10),domestic bivalirudin plus urokinase group (B&UK,n =10),and heparin plus urokinase group (H&UK,n =10).GMP-140 content and thrombus weight were detected before and after treatment.Results As compared with the model group,thrombus weight was obviously reduced in B&UK group and H&UK group.There was no significant difference in thrombus weight between B&UK group and H&UK group.GMP-140 content was remarkably greater in the model group,H&UK group,and B&UK gourp than in the control group.After treatment,GMP-140 content was significantly increased in H&UK gourp but obviously reduced in B&UK gourp.Conclusions Domestic bivalirudin can effectively inhibit formation of thrombosis in the rat model.As compared to heparin,domestic bivalirudin inhibits platelet activation function and platelet aggregation.During inhibition of thrombus formation,domcstic bivalirudin has more effects on platelet activation function.