摘要目的:探究ICU机械通气患者镇痛镇静中应用eCASH理念下作业指导书的研究效果分析。方法:选取2018年7月至2019年7月本院收治的ICU机械通气患者56例，采用随机法将患者分为对照组和试验组，每组28例。对照组采用常规镇静镇痛管理，试验组采用eCASH理念下作业指导书镇痛镇静管理，对比两组患者的ICU住院时间、机械通气时间、匹兹堡量表评分（PSQI）、谵妄发生率、一次性成功拔管率及疾病转归。结果:试验组患者机械通气时间、住院天数均显著短于对照组（均 P＜0.05）；试验组PSQI评分显著低于对照组（ P＜0.05）；试验组谵妄发生率显著少于对照组（7.14%比42.86%）（ P＜0.05）；试验组一次性拔管成功率（92.86%比60.71%）、转科率（89.29%比53.57%）显著优于对照组，两组比较差异均有统计学意义（均 P＜0.05）。 结论:将eCASH理念下作业指导书应用在ICU机械通气患者镇痛镇静中，能缩短机械通气时间，提高一次性拔管成功率，促进疾病康复。

abstractsObjective:To investigate the effect of the operation instruction of eCASH in the analgesia and sedation of patients with mechanical ventilation in ICU.Methods:From July 2018 to July 2019, 56 patients with mechanical ventilation in ICU were randomly divided into control group ( n=28) and experimental group ( n=28). The control group was treated with routine sedation and analgesia management, while the experimental group was treated with sedation and analgesia management with the operation instruction of eCASH. The hospitalization time, mechanical ventilation time, PSQI, delirium incidence, one-time successful extubation rate, and prognosis of disease of the two groups were compared. Results:The duration of mechanical ventilation and hospitalization in the experimental group were significantly shorter than those in the control group (all P<0.05); the PSQI score in the experimental group was significantly lower than that in the control group ( P<0.05); the incidence of delirium in the experimental group was significantly lower than that in the control group (7.14% vs. 42.86%) ( P<0.05); the one-time successful extubation rate and the rate of transferring to other departments in the experimental group were significantly better than those in the control group (92.86% vs. 60.71%, 89.29% vs. 53.57%) (all P<0.05). Conclusion:The application of the operation instruction of eCASH in the analgesia and sedation of patients with mechanical ventilation in ICU can shorten the time of mechanical ventilation, improve the one-time successful extubation rate, and promote the recovery of disease.