摘要炎症反应、免疫抑制、氧化应激等是脓毒症的主要致病机制.近年来研究发现,ω-3多不饱和脂肪酸(ω-3 polyunsaturated fatty acid,ω-3PUFA)可通过多种途径与花生四烯酸竞争,减少其代谢产物;通过改变细胞膜信号平台“脂筏”的性质、通过其代谢产物参与炎症的消退与组织修复,降低NF-κB的激活,抑制炎症反应.ω-3PUFA还能改善机体的抗氧化防御系统,减轻氧化应激.目前临床研究证实ω-3 PUFA能有效治疗脓毒症患者.该文就ω-3PUFA治疗脓毒症的具体机制作一综述.

abstractsInflammation,immune suppression and oxidative stress is the main pathogenesis of sepsis.In recent years,more study have found ω-3 polyunsaturated fatty acid(ω-3PUFA) can inhibit inflammation by some mechanisms namely,reducing metabolites from arachidonic acid(AA) by competing with it through a variety of ways,alteration of membrane lipid rafts,inhibition of nuclear receptor activation(specifically nuclear factor NF-κB)to modulate production of inflammatory mediators,and metabolism into novel pro-resolving and antiinflammatory mediators (resolvins and protectins).In addition,ω-3PUFA can reduce oxidative stress by improvement the antioxidant defense system,etc.Many clinical studies have demonstrated that ω-3PUF is effective in the for sepsis patients.The paper reviews the specific mechanism of ω-3PUFA treatment for sepsis.