摘要超极化激活的环核苷酸(hyperpolarization-activated cyclic nucleotide,HCN)通道是一个非选择性离子通道家族,普遍存在于心脏和神经系统中.HCN通道家族由于其超极化激活的特性在神经系统中发挥着独特的功能.研究表明HCN通道在突触信号的传递和整合中发挥着重要的作用.随着研究的不断深入,越来越多的证据表明敲除HCN1的小鼠的运动学习能力受到损害,但空间学习能力反而增强.其机制可能是由于小脑蒲肯野细胞的HCN1的缺失,也可能是海马突触环路中某个传导通路或某个神经节点中HCN1的缺乏.

abstractsHyperpolarization-activated cyclic nucleotide (HCN)-gated channels belong to a nonselective ion channel family,which are common in neurocyte and cardiac muscle cell.These channels play important roles in the nervous system because of their characterstics of hyperpolarization activation.Many studies have shown that HCN channels play key point in excitatory synaptic transmission and integration of output signal.With the development of research,more evidences have been found to prove that the motor learning is damaged and spatial learning ability is enhanced in HCN1 knockout mice.There are two potential mechanisms leading to these changes,one is the lack of HCN1 in cerebellum cell,and the other is the lack of HCN1 in trisynaptic circuits of hippocampus.