摘要近年来,儿童原发性高血压患病率增加迅速.高血压可造成靶器官损害,其中包括心、脑、肾等重要脏器.血管损伤是高血压靶器官损害的核心问题,其机制涉及到肾素-血管紧张素-醛固酮系统的激活、氧化应激反应、血管慢性炎症及内皮细胞功能障碍等.血管内皮细胞损伤可引起血管内皮功能障碍,其本质是内皮损伤和修复之间动态平衡的破坏,是心血管疾病发生发展的始动环节.循环内皮细胞和内皮祖细胞被认为是血管损伤、重塑以及内皮功能障碍的非侵入性标志物.该文通过总结相关文献,阐述原发性高血压患儿血管损伤与内皮细胞损伤之间的关系,深化对儿童原发性高血压的发病机制的认识.

abstractsIn recent years,primary childhood hypertension prevalence has increased rapidly.Hypertention can cause target organ damage,including heart,brain,kidney and other vital organs.Vascular injury is the core issue of hypertension target organ damage,and the mechanism involves the renin-angiotensin-aldosterone system activation,oxidative stress,chronic inflammation and vascular endothelial dysfunction,etc.Vascular endothelial cell damage can cause endothelial dysfunction,and its essence is the destruction of the dynamic balance between endothelial damage and repair,which is a link in the development of cardiovascular disease.Circulating endothelial cells and endothelial progenitor cells are considered to be non-invasive markers of vascular injury,remodelling and endothelial dysfunction.In this paper,we discuss the relationship between the vascular injtry with endothelial cell damage by summarizing the literature to deepen our understanding of the pathogenesis of essential hypertension in children.