摘要成纤维细胞活化蛋白（FAP）是一种具有二肽基肽酶和内肽酶活性的丝氨酸蛋白酶，常在肿瘤相关成纤维细胞中过表达。目前，放射性核素标记的成纤维细胞活化蛋白抑制剂（FAPI）PET/CT在肿瘤中的应用成为核医学研究的新热点。然而，FAP在活化的成纤维细胞中亦高表达，有关FAPI PET/CT在非肿瘤疾病（如心肌梗死、间质性肺纤维化疾病及免疫球蛋白G4相关疾病等）方面的研究取得了一定进展，且在疾病的早期诊断及疗效评估中具有潜在的应用前景。笔者就FAPI PET/CT在非肿瘤疾病中的应用及研究进展进行综述。

abstractsFibroblast activation protein (FAP) is a serine protease with dipeptidyl peptidase and endopeptidase activities, often overexpressed in tumor-associated fibroblasts. Currently, the use of radioisotope-labeled fibroblast activation protein inhibitors (FAPI) PET/CT in tumors has become a new hot spot in nuclear medicine research. However, FAP is also highly expressed in activated fibroblasts, and there has been some progress in the application of FAPI PET/CT in non-tumor diseases (such as myocardial infarction, interstitial pulmonary fibrosis diseases, and immunoglobulin G4-related diseases, etc), holding potential for in the early diagnosis and efficacy evaluation of these diseases. The authors review of the application and research progress of FAPI PET/CT in non-tumor diseases.