摘要目的 了解广州呼吸疾病研究所嗜麦芽窄食单胞菌分子流行病学与临床危险因素的关系.方法 回顾分析2008年3～4月呼吸科20株临床分离嗜麦芽窄食单胞菌的药敏结果.ERIC-PCR分析菌株的来源特征.分析患者的临床危险冈素包括基础疾病,抗生素治疗情况,机械通气史等.结果 20株嗜麦芽窄食单胞菌体外对亚胺培南、头孢噻肟、头孢吡肟、头孢曲松、氨曲南等100%耐药;对环丙沙星、阿米卡星、复方磺胺甲噁唑和米诺环素等的敏感性分别为65%、65%、85%和95%;ERIC-PCR显示20株嗜麦芽窄食单胞菌由17种不同克隆构成,药敏谱与基因型之间无显著相关性;患者临床资料显示其普遍具有易感性.结论 20株嗜麦芽窄食单胞菌分子流行病学调查显示其基因型多态性,未发现克隆株的传播;在严格的感染控制措施下,嗜麦芽窄食单胞菌小易出现克隆传播,降低临床危险因素对控制嗜麦芽窄食单胞菌发生至关重要.

abstractsObjective To investigate the epidemiological conditions of Stenotrophomonas mahophilia and their clinical risk factors in respiratory ward.Methods Antibiotic susceptibility data of Slmahophilia in respiratory ward and respiratorial ICU(RICU)ftom March to April 2008 was collected.Clinic isolates homology was analyzed by the method of ERIC-PCR.Retrospective analysis was made on the clinical risk factors including the underling diseases.the history of antibiotic treatment,the history of mechanical ventilation and ect.Results All Stenotrophomonas mahophilia strains showed resistance to imipenem,cefotaxime, cefepime,ceftriaxone,aztreonam;the resistance to Ciprofloxacin, amikacin,compound sulfamethoxazole,minocycline was 65%, 65%,85%, 95%;strains could be divided into 17 different clones by the method of ERIC-PCR,there was no correlation between susceptibility spectrum and genotype;the clinical data of patients showed they all had risk factors.Conclusions This survey revealed that there was a genotype polymorphism among all 20 strains of Stenotrophomonas mahophilia.Reducing the clinical risk factors was crucial for the control of Stenotrophomonas mahophilia.