摘要核转录因子κB (nuclear factor of kappa B,NF-κB)是一种广泛存在的核转录调节蛋白,它调控着与炎症、免疫、细胞增殖、分化和凋亡相关的多种基因的表达.NF-κB信号途径的激活与COPD的发生发展密切相关.抑制NF-κB信号途径的激活成为治疗COPD的新靶点,目前已发现多种药物通过干预NF-κB信号途径的不同位点来抑制其激活,从而可用于治疗COPD.本文综述了NF-κB及其信号途径的激活与抑制、NF-κB在COPD发病机制中的作用及通过阻断NF-κB信号途径来治疗COPD的各类药物.

abstractsNuclear factor of kappa B (NF-κB) is a kind of widespread nuclear transcription regulatory proteins,and it regulates the expression of multiple genes,including inflammation,immunity,cell proliferation,differentiation and apoptosis.The activation of NF-κB signaling pathway is closely related to the genesis and development of COPD.Inhibiting the activating of NF-κB signaling pathways become the new target for treatment of COPD.Now it has been found that a variety of drugs can inhibit the activating of NF-κB signaling pathways by intervening in different sites of NF-κB signaling pathway,which can be used in the treatment of COPD.This paper reviews the NF-κB and the activation and inhibition of its signal pathway,the pathogenesis of NF-κB signal pathway in COPD,and the treatment of various drugs in COPD by blocking NF-κB signaling pathways.