摘要脓毒症急性肺损伤（acute lung injury, ALI）发病急骤，是临床常见的急危重症。研究表明，线粒体动力学、内质网应激（endoplasmic reticulum stress, ERs）、高尔基体应激、溶酶体介导细胞自噬、外泌体分泌转移等细胞器功能障碍在脓毒症ALI发生发展的病理生理过程中发挥重要作用。血红素氧合酶-1（heme oxygenase-1, HO-1）及其催化产物一氧化碳（carbon monoxide，CO）是应激状态下细胞重要的内源性保护机制之一，通过发挥抗氧化应激、抗炎、抗凋亡等作用以减轻脓毒症ALI。文章主要阐述HO-1/CO系统对脓毒症ALI时细胞内各重要细胞器如线粒体、内质网、高尔基体、溶酶体、外泌体等的调控作用，为脓毒症ALI基于发病机制的治疗提供新途径和理论依据。

abstractsSepsis-induced acute lung injury (ALI) is a rapid onset, typical clinical intensive emergency. Studies have shown that mitochondrial dynamics, endoplasmic reticulum stress (ERs), Golgi apparatus stress, lysosome-mediated autophagy, exosome secretion and transfer play an essential role in the pathophysiological process of septic ALI. Heme oxygenase-1 (HO-1) and its catalytic byproducts, carbon monoxide (CO), are one of the crucial endogenous protective mechanisms of cells under stress, which can alleviate septic ALI through antioxidant, anti-inflammatory, and anti-apoptosis effects. This review mainly elaborates the role of HO-1/CO system in regulating the intracellular key organelles such as mitochondria, endoplasmic reticulum, golgi apparatus, lysosome, exosome in the settings of septic ALI, which provides a new approach and theoretical basis for the prevention and treatment of septic ALI.