摘要脂肪细胞型脂肪酸结合蛋白(FABP)4是脂肪酸结合蛋白家族中的一员,主要在脂肪细胞和巨噬细胞中表达,其表达受胰岛素、过氧化物酶体增殖物活化受体(PPAR)-γ激动剂的调控,可调节机体炎性反应,在体内脂肪酸转运和能量代谢中起重要作用.研究发现,FABP4能增加2型糖尿病的风险,预测血糖水平.同时,FABP4与2型糖尿病危险因素及糖尿病并发症的发生、发展也密切相关.

abstractsAdipocyte fatty acid-binding protein (FABP)4 blongs to a family of fatty acid-binding proteins,which is mainly expressed in adipocytes and macrophages.The expression of FABP4 can be regulated by insulin and peroxisome proliferator-activated receptor-gamma (PPAR)-γagonist.It could modulate inflammatory responses and was thought to be important in mediating intracellular fatty acid trafficking and energy metabolism.It was observed that FABP4 could increase the risk of type 2 diabetes mellitus and predict glycemic level.At the same time,FABP4 was significantly associated with occurrence and development of the risk factors of type 2 diabetes mellitus and its complications.