摘要饮食钠限制是预防或减缓糖尿病并发症发展的糖尿病护理的重要组成部分,许多国家糖尿病护理指南均提出了饮食钠摄入的建议,以期降低非传染病死亡率.然而,对于糖尿病患者饮食钠摄入量并无确切结论.对钠摄入量对糖尿病患者肾损伤的影响,包括近端肾小管对钠摄入量的敏感性变化、肾脏局部肾素-血管紧张素-醛固酮系统激活、胰岛素抵抗及相关细胞因子的释放进行总结,可为糖尿病患者肾损伤的预防和干预提出思路.

abstractsDietary sodium restriction is an important part of diabetes care to prevent or slow down the development of diabetic complications.Diabetes care guidelines in many countries have proposed dietary sodium intake in order to reduce non-communicable disease mortality.However,there is no definite conclusion about dietary sodium intake in diabetic patients.Summarizes the effects of sodium intake on renal injury in diabetic patients,including changes in sensitivity of proximal tubules to sodium intake,activation of renin-angiotensin-aldosterone system in the kidney,insulin resistance and the release of related cytokines,could provide ideas for the prevention and intervention of kidney injury in diabetic patients.