摘要表皮型脂氧合酶的12R-脂氧合酶和表皮型脂氧合酶3是哺乳动物脂氧合酶多基因家族成员.近年来研究发现,12R-脂氧合酶和表皮型脂氧合酶3可以通过花生四烯酸代谢途径参与皮肤的终末分化,调节皮肤屏障的发育、形成、功能及影响其外观与结构,并且在先天性鱼鳞病、银屑病等皮肤病发病机制中起作用.深入研究12R-脂氧合酶和表皮型脂氧合酶3与皮肤屏障的关系,以及研发选择性作用于二者基因靶点的新型药物将为某些干燥性皮肤病的治疗和保湿类化妆品的开发提供新的思路和方法.

abstracts12R-lipoxygenase(12R-LOX)and epidermis-type LOX3(eLOX3)are novel members of polygene family of mammalian lipoxygenases.Recent studies have shown that 12R-LOX and eLOX3 take part in terminal keratinocyte differentiation via arachidonic acid pathway,regulate the formation,development and function of,affect the appearance and structure of skin barrier.and play important roles in the pathogenes of manv dermatoses (e.g.congenital ichthyosis and psoriasis).Therefore,further investigation into the relationship between 12R-LOX,eLOX3 and skin barrier,as well as the development of novel drugs targeting on these genes would provide new ideas and methods for the treatment of xerosls and development of moisturizers.