摘要类脂质渐进性坏死是发生在真皮结缔组织的疾病,以小腿胫前的硬皮病样斑块为临床特征.其确切的发病机制不清楚,可能与糖尿病、免疫机制、胶原变性、血小板异常及创伤等多种因素有关.类脂质渐进性坏死同前尚无有效的治疗方法,糖皮质激素、免疫治疗、抗肿瘤坏死因子药物、光疗、延胡索酸酯及外科手术等有一定的疗效.

abstractsNecrobiosis lipoidica (NL) is a dermal connective tissue-involved disease characterized by scleroderma-like patches in the prctibial area. The pathogenesis of NL remains unclear, and is likely associated with diabetes mellitus, immunologic mechanism, collagen degeneration, blood plaque abnormality as well as trauma. No effective treatment is available for NL. Corticosteroid, immunotherapy, TNF antagonist, fumaric acid esters and surgical care may be applied in its treatment. This paper describes the latest progress in the research on NL pathogenesis, treatment and prognosis.