换一批摘要近来研究提示人类白细胞抗原等位基因是药物超敏反应的主要易感基因,与后者的发生有很强的遗传相关性.这种相关性具有药物特异性和种族特异性,表明在药物超敏反应的发生机制中,人类白细胞抗原分子起直接的作用.因此,对这些具有高度敏感性和特异性标记分子进行检测,可以鉴别个体发生药疹的风险.
更多相关知识
abstractsSeveral recent studies have suggested that human leukocyte antigen (HLA) alleles are major susceptible genes for drug hypersensitivity and there is a strong genetic associations between HLA alleles and drug eruption. The genetic association is drug and ethnicity specific, hinting a direct involvement of HLA in the pathogenesis of drug hypersensitivity. The high sensitivity/specificity of some molecular markers provides a plausible basis for developing tests to identify individuals at risk for drug eruption.
More相关知识
- 浏览273
- 被引0
- 下载148
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
