摘要白念珠菌是免疫力低下患者黏膜和系统的真菌致病源,侵袭性念珠菌感染有很强的致死性.即使是健康的个体,也容易感染阴道念珠菌病和其他皮肤黏膜念珠菌病.传统抗真菌药的疗效有一定的局限性和毒副作用,并且容易产生耐药.近年来,一些新型抗体疫苗已经研发并应用于动物模型和临床,表现出很好的对抗白念珠菌和协同传统抗真菌药物的作用.尽管其疗效和安全性还需要进一步验证,念珠菌抗体疫苗仍具有较好的临床应用前景,有望成为念珠菌病的辅助治疗手段.

abstractsCandida albicans is a major mucosal and systemic fungal pathogen in immunocompromisedhosts.Also.it often causes vaginal candidiasis and other mucosal and cutaneous candidiasis in healthy subjects.Invasive candidia infection has a high mortality.Some limimtions have been reported in the efficacy and safetyof convcntional antifungal agents with frequent emergence of resistance.Recently,some new antibody vaccineshave been developed and applied to animal models of and patients with potent anti-candida efficacy.Synergismhas been noticed between anti-candida vaccines and conventional antifungal agents.Though furtherconfirmation is required for the efficacy and safety,anti-candida vaccines have a perfect perspective in clinicalapplication.and is expected to be an adjunctive therapy of candidiasis.