摘要报告1例原发性皮肤CD4+多形性小/中T细胞淋巴瘤.患者男,19岁.全身多发暗红色斑块和小结节2年.皮损组织病理检查示,真皮内血管及附属器周围有致密小到中等大,胞质空亮,核扭曲的淋巴样细胞浸润,可见核分裂像.未见亲表皮性,但有浸润毛囊现象.免疫组化检查显示,CD3阳性、CD4阳性、CD8阴性、CD30阴性和CD20阴性,Ki-67阳性率约为25%.诊断:原发性皮肤CD4+多形性小/中T细胞淋巴瘤.

abstractsA case of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma is reported. A 19-year-old male presented with multiple dark-erythematous plaques and small nodules over the body for 2 years. Histopathology of the skin showed a diffuse dense infiltration of small/medium-sized lymphoid cells around dermal vessels and appendages. The lymphoid cells had clear cytoplasm and twisted nuclei.Mitotic figures were observed. Immunohistochemistry showed positive staining for CD3, CD4, but negative staining for CD8, CD30 and CD20. The positive staining rate for Ki-67 was 25%. A diagnosis of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma was made.