摘要患者女,46岁,双手背、手腕伸侧对称多数肤色小丘疹4年,不伴瘙痒、疼痛.皮肤组织病理检查:真皮浅中层胶原断裂,可见片状淡染物质沉积,未见成纤维细胞增生.阿新蓝染色显示:真皮浅中层胶原纤维间黏蛋白沉积,证实为肢端持续丘疹黏性蛋白沉积症.肢端持续丘疹黏蛋白沉积症属于皮肤黏蛋白沉积症局限型中的一个亚型,临床上需要与黏液水肿性苔藓散发丘疹型、皮肤局灶性黏蛋白沉积症及伴甲状腺病性黏蛋白沉积症进行鉴别.
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abstractsA case of acral persistent papular mucinosis (APPM)is reported. A 46-year-old woman presented with many cuticolor papules over bilateral hands and wrists for 4 years. No pruritus or tenderness was complained of. Histopathological examination revealed widely spaced collagen fibers and ill-defined lesions situated in the dermis, without fibroblastic proliferation. Alcian blue stain demonstrated mucin deposits in upper and mid dermis. A diagnosis of APPM was made. APPM is a subtype of localized cutaneous mucinosis.Other papular forms of mucinosis likely to be confused with APPM include a discrete papular form of lichen myxoedematosus, cutaneous focal mucinosis and a papular form of mucinosis with hypothyroidism.
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