摘要白藜芦醇是一种含有芪类结构的非黄酮类多酚化合物,它不仅是植物抗毒素,还具有抗癌、抗氧化、调节血脂等多种功能.体内外实验表明,白藜芦醇对黑素瘤起始、增殖、发展3个主要阶段均有抑制甚至逆转作用.其抗黑素瘤机制可以通过阻滞细胞周期、抗氧化、促进肿瘤细胞凋亡、诱导肿瘤细胞分化、干扰相关信号转导通路、抑制肿瘤血管生成等方面发挥作用.
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abstractsResveratrol, as a non-flavonoid polyphenolic compound,is not only a phytoalexin in plants,but also has antioxidant,anti-tumor,lipid-regulating activity.Recent in vivo and vitro studies have demonstrated that resveratrol can inhibit and even reverse melanoma initiation, promotion and progression.The anti-tumor effects of resveratrol may be mediated by resisting oxadation, blocking cell cycles, promoting apoptosis and inducing differentiation of tumor cells,interfering related signal transduction and inhibiting angiogenesis.
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