摘要人乳头瘤病毒感染是全球严重的公共卫生问题.近年人乳头瘤病毒预防性疫苗的成功为人乳头瘤病毒感染的预防与控制提供重要策略,但由于其对现症感染及所致疾病无效,人乳头瘤病毒治疗性疫苗的研发成为当今的热点.对目前研究的人乳头瘤病毒治疗性疫苗包括载体疫苗、肽疫苗、蛋白疫苗、DNA疫苗、RNA疫苗和细胞疫苗的研究进行概述,为人乳头瘤病毒疫苗研究提供参考.其中,蛋白疫苗安全性好、无人类白细胞抗原限制可以通过添加佐剂来提高疗效,应该是目前临床应用的首选.

abstractsHuman papillomavirus(HPV)infection has been a serious public health issue worldwide.Recent years prophylactic HPV vaccines have been proved to be successful as an important strategy for HPV prevention and control. However, prophylactic HPV vaccines do not have therapeutic effects against preexisting HVV infection and HPV-associated diseases, so it is important and urgent to develop effective therapeutic vaccines against HPV. This article reviews current progress of therapeutic HPV vaccines, including vector-based vaccines, peptide and protein based vaccines, DNA-based vaccines, RNA vaccines and whole cell vaccines. In consideration of safety, no restriction of HLA, enhanced potency by adjuvant, protein based vaccines attract scientists' eyes in clinical application in the near future.